Publications

*as the corresponding author

2023

106. Zhang, Y.; Huang, J.; Gan, L.; Wu, R.; Jin, J.; Wang, T.; Sun, S.; Zhang, Z.; Li, L.; Zheng, X.; Zhang, K.; Sun, L.; Ma, H.*; Li, D*. Hepatoprotective effects of Niudali (Callerya speciosa) root aqueous extracts against tetrachloromethane-induced acute liver injury and inflammation. Food Science & Nutrition, 2023, DOI: 10.1002/fsn3.3626.

105. Puopolo, T.; Li, H.; Gutkowski, J.; Cai, A.; Seeram, N. P.; Ma, H.; Liu, C. Establishment of human PD-1/PD-L1 blockade assay based on surface plasmon resonance (SPR) biosensor. Bio-protocol, 2023, 13(15). DOI: 10.21769/BioProtoc.4765

104. Chamcheu, J.C.; Ba, Q.; Ma, H*. Natural products modulate the sensitivity of cancer to anti-PD-1 based immunotherapy. Frontiers in Pharmacology, 2023. DOI: 10.3389/fphar.2023.1232456

103. Puopolo, T.; Li, H.; Ma, H.; Schrader, J.; Liu, C.; and Seeram, N. P. Uncovering the anti-inflammatory mechanisms of phenolic-enriched maple syrup extract in lipopolysaccharide-induced peritonitis in mice: Insights from data-independent acquisition proteomics analysis. Food & Function, 2023. 14, 6690-6706. DOI: 10.1039/D3FO01386C.

102. Ressler, A.J.; Frate, M.; Hontoria, A.; Ream, A.; Timms, E.; Li, H.; Stettler, L.D.; Bollinger, A.; Poor, J.E.; Parra, M.A.; Ma, H.; Seeram, N.P.; Meschwitz, S.M.; Henry, G.E. Synthesis, anti-ferroptosis, anti-quorum sensing, antibacterial and DNA interaction studies of chromene-hydrazone derivatives. Bioorganic & Medicinal Chemistry, 2023, 117369. DOI: 10.1016/j.bmc.2023.117369

101. Boateng, S.T; Roy, T.; Torrey, K.; Owunna, U.; Banang-Mbeumi, S.; Basnet, D.; Niedda, E.; Alexander, A.D.; Hage, D.E.; Atchimnaidu, S.; Nagalo, B.M.; Aryal, D.; Findley, A.; Seeram, N.P.; Efimova, T.; Sechi, M.; Hill, R.A.; Ma, H.; Chamcheu, J.C.; Murru, S. Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38:1, DOI: 10.1080/14756366.2023.2205042.

100. Jing, T., Zhang, Z., Kang, Z., Mo, J., Yue, X., Lin, Z., Fu, X., Liu, C., Ma, H.*, Zhang, X*. and Hu, W*. Discovery and optimization of novel biphenyl derivatives bearing cyclopropyl linkage as potent programmed cell death-1/programmed cell death-ligand 1 inhibitors. Journal of Medicinal Chemistry, 2023. DOI: 10.1021/acs.jmedchem.3c00205.

99. Bollinger, A.; Brandt, O.; Stettler, L.; Ream, A.; Kopysciansky, V.; Nelson, C.; Slitt, A.; Ma, J.; Tom, L.A.; Ma, H.; Seeram, N.P.; Henry, G.E. Sulfide-linked 3, 4, 5-trimethoxyphenyl-thiosemicarbazide/triazole hybrids: Synthesis, antioxidant, antiglycation, DNA cleavage and DNA molecular docking studies. Results in Chemistry, 2023, 100806. DOI: 10.1016/j.rechem.2023.100806

98. Torrey, K.J.; Liu, Y.; Li, H.; Ma, H.; Via, C.W.; Bertin, M.J.; Seeram, N.P. What is authentic maple water? A twelve-month shelf-life study of the chemical composition of maple water and its biological activities. Foods, 2023, 12, 239. DOI: 10.3390/foods12020239

2022

97. Wang, G.; Xu, J.; Ma, H.; Mu, Y.; Xu, W.; Yan, N.; Liu, W.; Zheng, D.; Huang, X.; Li, L.* Phenolipid JE improves metabolic profile and inhibits gluconeogenesis via modulating AKT-mediated insulin signaling in STZ-induced diabetic mice. Pharmacological Research, 2022, 106569. DOI: 10.1016/j.phrs.2022.106569

96. Saylor, J.L.; Basile, O.N.; Li, H.; Hunter, L.M.; Weaver, A.; Shellenberger, B.M.; Ann Tom, L.; Ma, H.; Seeram, N.P.; Henry, G.E., Phenolic furanochromene hydrazone derivatives: Synthesis, antioxidant activity, ferroptosis inhibition, DNA cleavage and DNA molecular docking studies. Bioorganic and Medicinal Chemistry, 2022, 75, 117088. DOI: 10.1016/J.BMC.2022.117088

95. Li, H.; Roy, T.; Boateng, S.T.; He, H.; Liu, C.; Liu, W.; Li, D.; Wu, P.; Seeram, N.P.; Chamcheu, J.C.; Ma, H*. Standardized pomegranate (Pomella®) and red maple (Maplifa®) extracts and their phenolics protect type I collagen by the inhibition of matrix metalloproteinases, collagenase, and collagen cross-linking. Molecules, 2022, 27, 7919. DOI: 10.3390/molecules27227919

94. Huang, S.; Li, H.; Xu, J.; Zhou, H.; Seeram, N.P.; Ma, H.*; Gu, Q*. Chemical constituents of industrial hemp roots and their anti-inflammatory activities. Journal of Cannabis Research, 2023, 5, DOI: 1. 10.1186/s42238-022-00168-3

93. Puopolo, T.; Chang, T.; Liu, C.; Li, H.; Liu, X.; Wu, X.; Ma, H.*; Seeram, N.P.* Gram-scale preparation of cannflavin A from hemp (Cannabis sativa L.) and its inhibitory effect on tryptophan catabolism enzyme kynurenine-3-monooxygenase. Biology, 2022, 11, 1416. DOI: 10.3390/biology11101416

92. Kirk, R.D.; Akanji, T.; Li, H.; Shen, J.; Allababidi, S.; Seeram, N.P.; Bertin, M.J.; Ma, H.* Evaluations of skin permeability of cannabidiol and its topical formulations by skin membrane-based parallel artificial membrane permeability assay and Franz cell diffusion assay. Medical Cannabis and Cannabinoids, 2022. DOI: 10.1159/000526769

91. Liu, C.; Puopolo, T.; Li, H.; Cai, A.; Seeram, N.P.*; Ma, H*. Identification of SARS-CoV-2 main protease inhibitors from a library of minor cannabinoids by biochemical inhibition assay and surface plasmon resonance characterized binding affinity. Molecules, 2022, 27, 6127. DOI: 10.3390/molecules27186127

90. Li, H.; Seeram, N.P.; Liu, C.*; Ma, H.* Further investigation of blockade effects and binding affinities of selected natural compounds to immune checkpoint PD-1/PD-L1. Frontiers in Oncology, 2022. DOI: 10.3389/fonc.2022.995461

89. Li, D.; Xu, Z.; Li, Y.; Gan, L.; Wu, P.; Wu, R.; Jin, J.; Zheng, X.; Zhang, K.; Ma, H.*; Li, L.* Polysaccharides from Callerya speciosa alleviate metabolic disorders and gut microbiota dysbiosis in diet-induced obese C57BL/6 mice. Food & Function, 2022, 13, 8662-8675 DOI: 10.1039/D2FO00337F.

88. Luan, F.; Peng, X.; Zhao, G.; Zeng, J.; Zou, J.; Rao, Z.; Liu, Y.; Zhang, X.; Ma, H.*; Zeng, N.* Structural diversity and bioactivity of polysaccharides from medicinal mushroom Phellinus spp.: A review. Food Chemistry, 2022, DOI: 10.1016/j.foodchem.2022.133731

87. Heider, C.G.; Itenberg, S.A.; Rao, J.; Ma, H.*; Wu, X.* Mechanisms of cannabidiol (CBD) in cancer treatment: A review. Biology, 2022, 11, 817. DOI: 10.3390/biology11060817

86. Lai, S.; Wang, Y.; Wan, Y.; Ma, H.; Fang, L.; Su, J.* Magnetoelectric polymer membrane-based electrical microenvironment with magnetically controlled antibacterial activity. ACS Applied Materials and Interfaces, 2022, DOI: 10.1021/acsami.2c04359

85. Luo, Z.; He, H.; Tang, T.; Zhou, J.; Li, H.; Seeram, N.P.; Li, D.; Zhang, K.; Ma, H.*; Wu, P.* Synthesis and biological evaluations of betulinic acid derivatives with inhibitory activity on hyaluronidase and anti-inflammatory effects against hyaluronic acid fragment induced inflammation. Frontiers in Chemistry, 2022, DOI: 10.3389/fchem.2022.892554

84. Puopolo, T.; Liu, L.; Ma, H.*; Seeram, N.P.* Inhibitory effects of cannabinoids on acetylcholinesterase and butyrylcholinesterase enzyme activities. Medical Cannabis and Cannabinoids, 2022, 5, 85–94. DOI: 10.1159/000524086

83. Liu, W.; Li, M.; Wang, G.; Ma, H.; Mu, Y.; Zheng, D.; Huang, X.; Li, L. New monoterpene acid and gallic acid glucose esters with anti-inflammatory activity from blue gum (Eucalyptus globulus) leaves. Journal of Agricultural and Food Chemistry, 2022. DOI: 10.1021/acs.jafc.2c00828

82. Liu, C.; Cai, A.; Li, H.; Deng, N.; Cho, B. P.; Seeram, N. P.; Ma, H.* Characterization of molecular interactions between cannabidiol and human plasma proteins (serum albumin and γ-globulin) by surface plasmon resonance, microcalorimetry, and molecular docking. Journal of Pharmaceutical and Biomedical Analysis, 2022, 114750.

81. Xue, L; Liu, C.; Ma, H.; Seeram, N.P.; Neto, C.C.* Anti-inflammatory activities of cranberry fruit extracts in human THP-1 monocytes are influenced by their phytochemical composition. ACS Food Science & Technology, 2022, 2, 75–83. DOI: 10.1021/acsfoodscitech.1c00324

2021

80. Li, H.; He, H.; Liu, C.; Akanji, T.; Gutkowski, J.; Li, R.; Ma, H.; Wan, Y.; Wu, P.; Li, D.; and Seeram, N.P., Ma, H.* Dietary polyphenol oleuropein and its metabolite hydroxytyrosol are moderate skin permeable elastase and collagenase inhibitors with synergistic cellular antioxidant effects in human skin fibroblasts. International Journal of Food Sciences and Nutrition, 2021. DOI: 10.1080/09637486.2021.1996542

79. Li, H.; Xu, F.; Liu, C.; Cai, A.; Dain, J.A.; Li, D.; Seeram, N.P.; Cho, B.P.; Ma, H.* Inhibitory effects and surface plasmon resonance-based binding affinities of dietary hydrolyzable tannins and their gut microbial metabolites on SARS-CoV-2 main protease. Journal of Agricultural and Food Chemistry. 2021, 69, 41, 12197-12208.

78. Xu, W.; Li, J.; Li, D.; Tan, J.; Ma, H.; Mu, Y.; Wen, Y.; Gan, L.; Huang, X.; and Li, L. Chemical characterization, antiproliferative and antifungal activities of Clinacanthus nutans. Fitoterapia. 2021, 105061. DOI: 10.1016/j.fitote.2021.105061

77. Wang, W.; Ren, Z.; Wang, L.; Cai, Y.; Ma, H.; Fang, L.; Su, J. Nanoparticle-stabilized encapsulation of borneol and citral: Physicochemical characteristics, storage stability, and enhanced antibacterial activities. Journal of Food Science, 2021, DOI: 10.1111/1750-3841.15910

76. He, H.; Li, H.; Akanji, T.; Niu, S.; Luo Z.; Li, D.; Seeram, N.P.; Wu, P.; Ma, H.* Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeability. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 1665-1678, DOI: 10.1080/14756366.2021.1956487

75. Ma, H.*; Li, H.; Liu, C; Seeram, N.P.* Evaluation of cannabidiol’s inhibitory effect on alpha-glucosidase and its stability in simulated gastric and intestinal fluids. Journal of Cannabis Research, 2021, 3, 20. DOI: 10.1186/s42238-021-00077-x

74. Guo, H.; Liu, C.; Tang, Q.; Li, D.; Wan, Y.; Li, J. H.; Gao, X.H.; Seeram, N.P.; Ma, H.* & Chen, H. D.* Pomegranate (Punica granatum) extract and its polyphenols reduce the formation of methylglyoxal-DNA adducts and protect human keratinocytes against methylglyoxal-induced oxidative stress. Journal of Functional Foods, 2021, 83, 104564.

73. Johnson, S.L.; Lu, Y.; Ma, H.; Seeram, N.P.; & Yuan, T. Compounds from Mucuna pruriens seeds and their neuroprotective effects. Chemistry of Natural Compounds, 2021, doi:10.1007/s10600-021-03425-8

72. Liu, C.; Seeram, N. P.; & Ma, H.* Small molecule inhibitors against PD-1/PD-L1 immune checkpoints and current methodologies for their development: A review. Cancer Cell International, 2021, 21, 1-17.

71. Liu, C.; Li, H.; Xu, F.; Jiang, X.; Ma, H.*; & Seeram, N. P. Cannabidiol protects human skin keratinocytes from hydrogen-peroxide-induced oxidative stress via modulation of the caspase-1–IL-1β axis. Journal of Natural Products, 2021, 84, 5, 1563–1572

70. Li, Y.; Xu, J.; Li, D.; Ma, H.; Mu, Y.; Zheng, D.; Huang X.; Li Y. Chemical characterization and hepatoprotective effects of a standardized triterpenoid-enriched guava leaf extract. Journal of Agricultural and Food Chemistry, 2021. DOI: 10.1021/acs.jafc.0c07125

2020

70. Wu, P.; He, H.; Ma, H.; Tu, B.; Li, J.; Guo, S.; Chen, S.; Cao, N.; Zheng, W.; Tang, X; and Li, D., Xu, X.; Zheng, X.; Sheng Z.; Hong, W.D.; Zhang, K. Oleanolic acid indole derivatives as novel α-glucosidase inhibitors: synthesis, biological evaluation, and mechanistic analysis. Bioorganic Chemistry, 2020, 104580. DOI: 10.1016/j.bioorg.2020.104580

69. Marisa Pfohl, M.; DaSilva, N.A.; Marques, E.; Agudelo, J.; Liu, C.; Goedken, M.; Slitt, A.L.; Seeram, N.P.*; Ma, H.* Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice. International Journal of Food Sciences and Nutrition, 2020, DOI: 10.1080/09637486.2020.1849041

68. Liu, C.; Xu, Y.; Kirk, R.D.; Li, H.; Li, D.; DaSilva, N.A.; Bertin, M.J.; Seeram, N.P. and Ma, H.* Inhibitory effects of skin permeable glucitol-core containing gallotannins from red maple leaves on elastase and their protective effects on human keratinocytes. Journal of Functional Foods, 2020, 75, 104208. DOI: 10.1016/j.jff.2020.104208

67. Li, Y.; Xu, J.; Li, D.; Ma, H.; Mu, Y.; Huang, X.; Li, L. Guavinoside B from Psidium guajava alleviates acetaminophen-induced liver injury via regulating Nrf2 and JNK signaling pathways. Food & Function, 2020, DOI: 10.1039/D0FO01338B.

66. Johnson, S.; Park, H.; Vattem, D.A.; Grammas, P.; Ma, H.*; Seeram, N.P.* Equol, a blood–brain barrier permeable gut microbial metabolite of dietary isoflavone daidzein, exhibits neuroprotective effects against neurotoxins induced toxicity in human neuroblastoma SH-SY5Y cells and Caenorhabditis elegans. Plant Foods for Human Nutrition, 2020, DOI:10.1007/s11130-020-00840-0

65. Li, H.; DaSilva, N.A.; Liu, W.; Xu, J.; Dombi, G.W.; Dain, J.A.; Li, D.; Chamcheu, J.C.; Seeram, N.P.; Ma, H.* Thymocid®, a standardized black cumin (Nigella sativa) seed extract, modulates collagen cross-linking, collagenase and elastase activities, and melanogenesis in murine b16f10 melanoma cells. Nutrients, 2020, 12, 2146. doi.org/10.3390/nu12072146

64. Muhsinah, A.B.; Alfarius, E.N.; Li, H.; Lazzaro, S.; DaSilva, N.A.; Li, D.; Ma, H.; Alsayari, A.; Morita, H.; Liu, Y.*; Seeram, N.P.* Saudiarabicains A-E, bioactive 19-acetoxyingol diterpenoids from Euphorbia saudiarabica. Tetrahedron Letters, 2020, DOI: 10.1016/j.tetlet.2020.152203

63. Ma, H.*; Xu, F.; Liu, C.; Seeram, N.P. A network pharmacology approach to identify potential molecular targets for cannabidiol’s anti-inflammatory activity. Cannabis and Cannabinoids Research, 2020, DOI: 10.1089/can.2020.0025

62. Killian, C.; Johnson, S. L.; Ma, H.; McKeown, B.; McDougall, L.; Hurta, R.; Liu, Y. *; Seeram, N. P.* Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa. Natural Product Research, 2020, DOI: 10.1080/14786419.2020.1784174

61. Liu, C.; Ma, H.*; Slitt A.L.*; Seeram, N.P.* Inhibitory effect of cannabidiol on the activation of NLRP3 inflammasome is associated with its modulation of the P2X7 receptor in human monocytes. Journal of Natural Products, 2020. DOI: 10.1021/acs.jnatprod.0c00138.

60. Liu, C.; Guo, H.; Dain, J. A.; Wan, Y.; Gao, X. H.; Chen, H. D.; Seeram, N. P.; Ma, H.* Cytoprotective effects of a proprietary red maple leaf extract and its major polyphenol, ginnalin A, against hydrogen peroxide and methylglyoxal induced oxidative stress in human keratinocytes. Food & Function, 2020, DOI:10.1039/d0fo00359j

59. Li, L.; Ma, H.; Liu, T.; Ding, Z.; Liu, W.; Gu, Q.; Mu, Y.; Xu, J.; Seeram, N.P.; Huang, X. and Xu, J. Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice. Journal of Functional Foods, 2020, 70, 103970. DOI:10.1016/j.jff.2020.103970

58. Sheng, J.; Liu, C.; Petrovas, S.; Wan, Y.; Chen, H.D.; Seeram, N.P. and Ma, H.* Phenolic-enriched maple syrup extract protects human keratinocytes against hydrogen peroxide and methylglyoxal induced cytotoxicity. Dermatologic Therapy, 2020, DOI:10.1111/dth.13426

57. Li, D.; Tang, X.; Liu, C.; Li, H.; Li, S.; Sun, S.; Zheng, X.; Wu, P.; Xu, X.; Zhang, K.; Ma, H*. Jasmine (Jasminum grandiflorum) flower extracts ameliorate tetradecanoylphorbol acetate induced ear edema in mice. Natural Product Communications, 2020, 15, 1-7. DOI: 10.1177/1934578X20917498

56. Espinosa, A.; Santos, Y.; Ma, H.; Nadeau, M.; Seeram, N.P.; Rowley, D.C. 2020. Anti-amebic effects of Chinese rhubarb (Rheum palmatum) leaves' extract, the anthraquinone rhein and related compounds. Heliyon, 2020, 6, p.e03693. DOI: 10.1016/j.heliyon.2020.e03693

55. Fan, Q.; Liu, Y.; Wang, X.; Zhang, Z.; Fu, Y.; Liu, L.; Wang, P.; Ma, H.; Ma, H.*; Seeram, N.P.; Zheng, J.; Zhou, F.* Ginnalin A inhibits aggregation, reverses fibrillogenesis and alleviates cytotoxicity of amyloid β(1–42). ACS Chemical Neuroscience, 2020, 11, 638-647. DOI: 10.1021/acschemneuro.9b00673

Prior to 2020

54. Xu, W.; Zhang, L.; Omar R.; Liu, W.; Wei, Z.; Zhang Z.; Mu, Y.; Seeram, N.P.; Huang, X.; Ma, H.*; Li, L. Barringtogenol C-type triterpenoid saponins from the stem bark of Norway maple (Acer platanoides). Planta Medica, 2019, 86, 70-77., DOI: 10.1055/a-1031-7283

53. Rose, K.N.; Barlock, B.J.; DaSilva, N.A.; Johnson, S.L.; Liu, C.; Ma, H.; Nelson, R.; Akhlaghi, F.; Seeram, N.P. Anti-neuroinflammatory effects of a food-grade phenolic-enriched maple syrup extract in a mouse model of Alzheimer’s disease. Nutritional Neuroscience, 2019, 4, 1-10. DOI: 10.1080/1028415X.2019.1672009

52. Li, Y., Li, D., An, Q., Ma, H., Mu, Y., Qiao, W., Zhang, Z., Zhang, J., Huang, X.; Li, L. New acylated phenolic glycosides with ROS scavenging activity from Psidium guajava leaves. Journal of Agricultural and Food Chemistry, 2019, 67, 11089-11098. DOI: 10.1021/acs.jafc.9b04318

51. Chen, M.; Qin, Y.; Ma, H.; Zheng, X.; Zhou, R.; Sun, S.; Huang, Y.; Duan, Q.; Liu, W.; Wu, P.; Xu, X.; Sheng, Z.; Zhang, K.; Li, D. Downregulating NF-κB signaling pathway with triterpenoids for attenuating inflammation: in vitro and vivo studies. Food & Function, 2019. DOI: 10.1039/c9fo00561g

50. Johnson, S. L.; Kirk, R. D.; DaSilva, N. A.; Ma, H.; Seeram, N. P.; Bertin, M. J. Polyphenol microbial metabolites exhibit gut and blood–brain barrier permeability and protect murine microglia against LPS-induced inflammation. Metabolites, 2019, 9, 78. DOI: 10.3390/metabo9040078

49. Chen, F.; Tang, Q.; Ma, H.; Bian, K.; Seeram, N. P.; & Li, D. Hydrolyzable tannins are iron chelators that inhibit DNA repair enzyme ALKBH2. Chemical Research in Toxicology, 2019, 32, 1082-1086.

48. Xu, J.; Liu, T.; Li, Y.; Liu, W.; Ding, Z.; Ma, H.; P. Seeram, N. P.; Mu, Y.; Huang, X.; Li, Y. Jamun (Eugenia jambolana Lam.) fruit extract prevents obesity by modulating the gut microbiome in high-fat diet-fed mice. Molecular Nutrition and Food Research, 2019, DOI: 10.1002/mnfr.201801307

47. Brotzman, N.; Xu, Y.; Graybill, A.; Cocolas, A.; Ressler, A.; Seeram, N. P.; Ma, H.; Henry, G. E. Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol. Bioorganic & Medicinal Chemistry Letters, 2019, 29, 56-58.

46. Liu, C.; Guo, H.; DaSilva, N. A.; Li, D.; Zhang, K.; Wan, Y.; Gao, X.; Chen, H.; Seeram N. P.; Ma, H.* Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes. Journal of Functional Foods, 2019, 54, 559-567.

45. Liu, W.; Cai, A.; Carley, R.; Rocchio, R.; Petrovas, Z. M.; Chartier, C. A.; Meng, X.; Su, J.; Cho, B.P.; Dain, J. A.; Ma, H.*; Seeram, N. P. Bioactive anthraquinones found in plant foods interact with human serum albumin and inhibit the formation of advanced glycation endproducts. Journal of Food Bioactives, 2018, 4, 130-138.

44. Guo, H.; Qi, R.; Sheng, J.; Liu, C.; Ma, H.; Wang, H.; Li, J.; Gao, X.; Wan, Y.; Chen, H. 2018 MiR-155, a potential serum marker of extramammary Paget’s disease. BMC Cancer, 18, 1078. doi.org/10.1186/s1288

43. Brotzman, N.; Xu, Y.; Graybill, A.; Cocolas, A.; Ressler, A.; Seeram, N. P.; Ma, H.; Henry, G. E. Synthesis and tyrosinase inhibitory activities of 4-oxobutanoate derivatives of carvacrol and thymol. Bioorganic & Medicinal Chemistry Letters, 2018, 29, 56-58.

42. Johnson, S.; Park, H.; DaSilva, N.; Vattem, D., Ma, H.; Seeram, N.P. Levodopa-reduced Mucuna pruriens seed extract shows neuroprotective effects against Parkinson’s disease in murine microglia and human neuroblastoma cells, Caenorhabditis elegans, and Drosophila melanogaster. Nutrients, 2018, 10, 1139. doi.org/10.3390/nu10091139

41. Rose, K.; Wan, C.; Thomas, A.; Seeram, N. P.; Ma, H.* Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective activities. Natural Product Communications, 2018, 13, 1309-1311.

40. Luo, J.; Meng, X.; Su, J.; Ma, H.; Wang, W.; Fang, L.; Zheng, H.; Qin, Y.; Chen, T. Biotin modified PLGA nanoparticles with improved antiproliferative activity of 15,16-dihydrotanshinone I in human cervical cancer cells. Journal of Agricultural and Food Chemistry, 2018, 35, 9219-9230.

39. Liu, F.; Ma, H.; Wang, G.; Liu, W.; Seeram, N.P.; Mu, Y.; Xu, Y.; Huang, X; Li, L. Phenolics from Eugenia jambolana seeds with advanced glycation endproduct formation and alpha-glucosidase inhibitory activities. Food & Function, 2018, 9, 4246-4254.

38. Yao, H.; Zhang, W.; Wu, H.; Yang, M.; Wei, P.; Ma, H.; Duan, J.; Zhang, C.; Li, Y. Sikokianin A from Wikstroemia indica protects PC12 cells against OGD/R-induced injury via inhibiting oxidative stress and activating Nrf2. Natural Product Research, 2018, DOI: 10.1080/14786419.2018.1480019

37. Meng, X.; Dong, X.; Wang, W.; Yang, L.; Zhang, X., Li, Y.; Chen, T.; Ma, H.; Qi, D.; Su, J. Natural borneol enhances paclitaxel-induced apoptosis of ESCC cells by inactivation of the PI3K/AKT. Journal of Food Science, 83, 1436-1443.

36. Xu, J.; Liu, T.; Li Y.; Yuan, C.; Ma, H.; Seeram, N.P.; Liu, F.; Mu Y.; Huang, X.; Li, L. Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (Eugenia jambolana Lam.) fruit extract in Streptozotocin-induced type 1 diabetic mice. Food & Function, 2018, 9, 3330-3337.

35. Ma, H.; Johnson, S.L.; Liu, W.; DaSilva, N.A.; Meschwitz, S.; Dain, J.A.; Seeram, N.P. Evaluation of blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts for free radical scavenging, reactive carbonyl species trapping, anti-glycation, anti-β-amyloid aggregation, and microglial neuroprotective effects. International Journal of Molecular Sciences, 2018, 19, 461, DOI:10.3390/ijms19020461

34. Luo, X.K.; Cai, J.; Yin, Z.Y.; Luo, P.; Li, C.J.; Ma, H.; Seeram, N.P.; Gu, Q.; Xu, J. Fluvirosaones A and B, two indolizidine alkaloids with a pentacyclic skeleton from Flueggea virosa. Organic Letters, 2018, 20, 991-994.

33. Xu, J.; Yuan, C.; Wang, G.; Luo, J.; Ma, H.; Xu, L.; Mu, Y.; Li, Y.; Seeram, N.P.; Huang, X.; Li, L. Urolithins attenuate LPS-induced neuroinflammation in BV2 microglia via MAPK, Akt, and NF-κB signaling pathways. Journal of Agricultural and Food Chemistry, 2018, 66, 571–580.

32. Liu, F.; Liu, C.; Liu, W.; Ding, Z.; Ma, H.; Seeram, N.P.; Xu, L.; Mu, Y.; Huang, X.; Li, L. New sesquiterpenoids from Eugenia jambolana seeds and their anti-microbial activities. Journal of Agricultural and Food Chemistry, 2017, 65, 10214-10222.

31. DaSilva, N.A.; Nahar, P.P.; Ma, H.; Eid, A.; Wei, Z.; Meschwitz, S.; Zawia, N.H.; Slitt, A.L; Seeram, N.P. Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro. Nutritional Neuroscience, 2017, 185-195.

30. Kim, B.; Bae, M.; Park, Y. K.; Ma, H.; Yuan, T.; Seeram, N. P.; Lee, J. Y. Blackcurrant anthocyanins stimulated cholesterol transport via post-transcriptional induction of LDL receptor in Caco-2 cells. European Journal of Nutrition, 2018, 57, 405–415.

29. Ma, H.*; Xu, J.; DaSilva, N.A.; Wang, L.; Wei, Z.; Guo, L.; Johnson, S.L.; Lu, W.; Xu, J.; Gu, Q.; Seeram, N.P. Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells. Archives of Dermatological Research, 2017, 309, 265-274.

28. Liu, W.‡; Wei, Z. ‡; Ma, H.‡; Cai, A.; Liu, Y.; Sun, J.; DaSilva, N.A.; Johnson, S.L.; Kirschenbaum, L.J.; Cho, B.P.; Dain, J.A.; Rowley, D.C.; Shaikh, Z.A., Seeram, N.P. Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells. Food & Function, 2017, 8, 757-766. ‡Equal contribution

27. Muhsinah, A.; Ma, H.; DaSilva, N.A.; Yuan, T.; Seeram, N.P. Bioactive glucitol-core containing gallotannins and other phytochemicals from Silver maple (Acer saccharinum) leaves. Natural Products Communications, 2016, 12, 83-84.

26. Li, Y.; Xu, J.; Yuan, C.; Ma, H.; Liu, T.; Liu, F.; Seeram, N.P.; Mu, Y.; Huang, X.; Li, L. Chemical composition and anti-hyperglycaemic effects of triterpenoid enriched Eugenia jambolana Lam. berry extract. Journal of Functional Foods, 2017, 28, 1-10.

25. Liu, S.N.; Huang, D.; Morris-Natschke, S.L.; Ma, H.; Liu, Z.H.; Seeram, N.P.; Xu, J.; Lee, K.H.; Gu, Q. Euphomilones A and B, ent-rosane diterpenoids with 7/5/6 and 5/7/6 skeletons from Euphorbia milii. Organic Letters, 2016, 23, 6132-6135.

24. Luo, X.; Li, C.; Luo, P.; Lin, X.; Ma, H.; Seeram, N.P.; Song, C.; Xu, J.; Gu, Q. Pterosin sesquiterpenoids from Pteris cretica as hypolipidemic agents via activating liver X receptors. Journal of Natural Products, 2016, 79, 3014-3021.

23. Liu, W. ‡; Ma, H. ‡; DaSilva, N. A.; Rose, K. N.; Johnson, S. L.; Zhang, L.; Dain, J. A.; Seeram, N. P. Development of a neuroprotective potential algorithm for medicinal plants. Neurochemistry International, 2016, 100, 164-177. ‡Equal contribution

22. Sun, J.; Ma, H.; Seeram, N. P.; Rowley, D. C. Detection of inulin, a prebiotic polysaccharide in maple syrup. Journal of Agricultural and Food Chemistry, 2016, 64, 7142-7147.

21. Ma, H.; DaSilva, N.; Liu, W.; Nahar, P.P., Wei, Z.; Liu, Y.; Pham, T.P.; Crews, P.; Vattem, D.A.; Slitt, A.L.; Shaikh, Z.; Seeram, N.P. Effects of a phenolic-enriched maple syrup extract on β-amyloid aggregation, neuroinflammation in murine and neuronal cells, and β-amyloid induced neurotoxicity in Caenorhabditis elegans. Neurochemical Research, 2016, 41, 2836-2847.

20. Liu, Y.; Ma, H.; Seeram, N.P. Development and UFLC-MS/MS characterization of a product specific standard for phenolic quantification of maple food products. Journal of Agricultural and Food Chemistry, 2016, 65, 3311-3317.

19. Ma, H.; Liu, W.; Frost, L.; Kirshenbaum, L.; Dain, J.; Seeram, N.P. Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential, Food & Function, 2016, 7, 2213-2222. Hot Article in Food & Function 2016

18. Sun, J.D.; Liu, W.; Ma, H.; Marais, J.; Khoo, C.; Dain, J.; Rowley, D.C.; Seeram, N.P. Effect of cranberry (Vaccinum macrocarpon) oligosaccharides on the formation of advanced glycation endproducts. Journal of Berry Research, 2016, 6, 149-158.

17. Skrip, M.M.; Seeram, N.P.; Yuan, T.; Ma, H.; McWilliams, S.R. Dietary antioxidants and flight exercise affect how female birds allocate nutrients to eggs: how carry-over effects work. Journal of Experimental Biology, 2016, 219, 2716-2725.

16. Deering, R.W.; Chen, J.; Sun, J.; Ma, H.; Dubert, J.; Barja, J.L.; Seeram, N.P.; Wang, H.; Rowley, D.C. N-acyl dehydrotyrosines, tyrosine inhibitors from the marine bacterium. Thalassotalea sp. PP2-459. Journal of Natural Products, 2016, 79, 447-450.

15. Yuan, T.; Ma, H.; Liu, W.; Niesen, D.B.; Shah, N.; Crews, R.; Rose, K.N.; Vattem, D.A.; Seeram, N.P. Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites. ACS Chemical Neurosciences, 2016, 7, 26-33.

14. Ma, H.; Wang, L.; Niesen, D.B.; Cai, A.; Cho, B.P.; Tan, W.; Gu, Q.; Xu, J.; Seeram, N.P. Structure activity related, mechanistic and modeling studies of gallotannins containing a glucitol core and a-glucosidase. RSC Advances, 2015, 5, 107904-107915.

13. Zhang, Y.; Ma, H.; Liu, W.; Yuan, T.; Seeram, N.P. New antiglycative compounds from cumin (Cuminum cyminum) spice. Journal of Agricultural and Food Chemistry, 2015, 63, 10097- 10102.

12. Zhang, L.; Tu, Z-C.; Yuan, T.; Ma, H.; Niesen, D.B.; Wang, H.; Seeram, N.P. New gallotannin and other phytochemicals from sycamore maple (Acer pseudoplatanus) leaves. Natural Products Communications, 2015, 10, 1977-1980.

11. Zhang, Y. ‡; Ma, H.‡; Yuan, T.; Seeram, N.P. Red maple (Acer rubrum) aerial parts as a source of bioactive phenolics. Natural Products Communications, 2015, 10, 1409-1412. ‡Equal contribution

10. Ma, H.; Liu, W.; Frost, L.; Wang, L.; Kong, L.; Dain, J.A.; Seeram, N.P. The hydrolyzable gallotannin, penta-O-galloyl-β-D-glucopyranoside inhibits the formation of advanced glycation endproducts by protecting protein structure. Molecular BioSystems, 2015, 11, 1338-1347.

9. Niesen, D.B.; Ma, H.; Yuan, T.; Bach II, A.C.; Henry, G.E.; Seeram, N.P. Phenolic constituents of Carex vulpinoidea seeds and their tyrosinase inhibitory activities. Natural Products Communications, 2015, 3, 491-493.

8. Liu, W.‡; Ma, H.‡; Frost, L.; Yuan, T.; Dain, J.A.; Seeram, N.P. Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species. Food & Function, 2014, 5, 2996-3004. ‡Equal contribution

7. Guo, L.; Panderi, I.; Yan, D.D.; Szulak, K.; Li, Y.; Chen, Y.T.; Ma, H.; Niesen, D.B.; Seeram, N.; Ahmed, A.; Yan, B.; Pantazatos, D.; Lu, W. A comparative study of hollow copper sulfide nanoparticles and hollow gold nanospheres on degradability and toxicity. ACS Nano, 2013, 7, 8780-8793.

6. Yuan, T.; Wan, C.; Ma, H.; Seeram, N.P. Novel phenolics from the flowers of Punica granatum and their α-glucosidase inhibitory activities, Planta Medica, 2013, 79, 1-6.

5. González-Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S- and G2/M-cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels. Food Chemistry, 2013, 136, 636-642.

4. Ma, H.; Tao, Y.; González-Sarrías, A.; Li, L.; Edmonds, M.E.; Seeram, N.P. New galloyl derivative from winged sumac (Rhus copallinum) fruit. Natural Products Communications, 2012, 7, 45-46.

3. Guo, L.; Fan, L.; Ren, J.; Pang, Z.; Ren, Y.; Li, J.; Wen, Z.; Qian, Y.; Zhang, L.; Ma, H.; Jiang, X., Combination of TRAIL and actinomycin D liposomes enhances antitumor effect in non-small cell lung cancer. International Journal of Nanomedicine, 2012, 7, 1449-60.

2. Jean-Gilles, D.; Li, L.; Ma, H.; Yuan, T.; Chichester, C.O.; Seeram, N.P. Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. Journal of Agricultural and Food Chemistry, 2012, 60, 5755-5762.

1. Ma, H.; Li, L.; Seeram, N.P. Phenolics from Cornus amomum Mill. fruit. Biochemical Systematics and Ecology, 2010, 38, 1083-1084.